| Contract
number |
|
BRPR-CT97-0415 |
Proposal
number |
|
BE-3642 |
| RTD
programme |
|
Brite-EuRam |
|
Organisation |
|
Biomatech SA |
| Partner |
|
University of Milan, IT |
| Partner |
|
Royal Technical High
School Stockholm, SW |
| Partner |
|
Humboldt-Universitat zu
Berlin, D |
| Partner |
|
University of Patras, GR |
| Partner |
|
Universite Claude Bernard
Lyon 1, FR |
| Partner |
|
Forbairt Ceramics Research
Centre, I |
| Partner |
|
Landbouwuniversiteit
Wageningen, NL |
| Partner |
|
University of Siena, I |
| Summary |
|
Medical Devices represent
half of the nosocomial complications in the |
|
hospital. They are related
to a relative affinity of bacteria to adhere on |
|
an artificial surface, and
to develop a biofilm structure which isolates |
|
micro-organisms from
conventional therapies. End-users and |
|
industrials are highly
concerned by morbidity and health care costs of |
|
infection. This
fundamental research program is dealing with the |
|
screening of more than 10
different surface treatment for polymers in |
|
order to design an
“anti-bacterial” interface. These techniques of |
|
potential interest in
developing antibacterial surfaces will include:- |
|
Design of specific
antibacterial activity (silver, quaternary ammonium, |
|
carbon-like coatings + Ag,
silver iodide, antiseptics). |
|
Grafting of biological
molecules within the bulk or on the surface |
|
(heparin is of high
potential interest). |
|
Development of non-fouling
surfaces concept (PEO-like, PEO repelling, |
|
Teflon like,
suprahydrophillic, microstructured). The activity of these |
|
materials will be screened
on bacterial strains and in conditions |
|
representative of clinical
use. A fundamental approach of biofilm |
|
expression and regulation
according to the different polymeric |
|
surfaces and treatments is
included as an important step for the |
|
understanding of the
effects. |
Previous Next Last
  
|
