| Contract
number |
|
BRE2-CT94-0607 |
Proposal
number |
|
BE-8000 |
| Start
date |
|
01-May-94 |
Duration |
|
3 years |
| RTD
programme |
|
Brite-EuRam |
|
Organisation |
|
Biomatech SA |
| Street |
|
Zone Industrielle de
l'Islon |
| Country |
|
France |
Postcode |
|
F-38670 |
| Telephone |
|
33 4 78079234 |
Fax |
|
33 4 72240812 |
| Summary |
|
The project is concerned
with understanding the factors involved in |
|
carcinogenicity and the
potential of biomaterials to initiate tumour |
|
formation. It also is
aimed at developing and validating a reliable test |
|
procedure that assesses
carcinogenic risk. The general objectives are |
|
focused on the development
and validation of: |
|
1. an early molecular or
cellular criteria of tumo-rigenesis |
|
2. an in vitro assay for
early screening of risk |
|
3. an adequate in vivo
protocol to confirm in vitro results using |
|
4. a proposal for revision
of the relevant European and/or |
|
International Standards
and/or guidelines for assessment of |
| Achievements |
|
A range of biomaterials,
already in clinical use, have been selected as |
|
“reference”
materials, and chemically characterised and implanted in |
|
animal models. The
provision of molecular markers which can detect |
|
changes in cells (around
the sites of implantation) at the molecular and |
|
gene expression level has
been examined. Retrospective analyses of |
|
explant tissues have been
made in order to investigate “real” cellular |
|
reactions and,
potentially, allow correlations to be drawn. The products |
|
of in vitro corrosion
around metals, with associated levels of cytoxicity, |
Previous Next Last
  
|
