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 Bioerodible-biodegradable polymeric matrices for targeted protein

drug release
Contract number
BRE-CT94-0530 Proposal number
BE-7052
Start date
01-Jul-94 Duration
3 years
RTD programme
Brite-EuRam
Budget ECU
2949388
Coordinator
Professor E Chiellini

Organisation
Universita Degli Studi di Pisa

Department
Dipartimento di Chimica E Chimica Industriale
Street
Via Risorgimento 35
City
Pisa
Country
Italy Postcode
I-56126
Telephone
39 050 918111 / 918299 Fax
39 050 28438/918260
Email
chimeo@dcci.unipi.it
Web_address
Partner
Isierovac, I
Partner
Polymer Laboratories Ltd, UK
Partner
Scotia LipidTeknik AB, SE
Summary
The aims of this project include preparation on laboratory scale of new

polymeric matrices for the formulation of

biocompatible-bioerodible-biodegradable microcapsules and

nanocapsules (microcaps) as designed for the targeted release of

proteic drugs. The ultimate target is IFN? administration to liver

hepatocytes in patients affected by hepatitis-C.
Achievements
The following results have been achieved:

1. lab-scale and scale-up procedures have been devised for the

preparation of bioerodible/biodegradable new co-polymeric materials.

2. formulation of stabilised microcapsules and nanocapsules

(microcaps) has been achieved, using some of the hybrid materials of

choice.

3. investigation has been carried out of the interactions of the prepared

microcaps with hepatocytes from rats.

4. a biodistribution study of microcaps in vivo (rabbit) showed a

selective accumulation in liver hepatocytes.
5. 3D molecular dynamics modeling of nanocapsules stabilization by modified b-cyclodextrins and docking of labelled nanocapsules to asialoglycoprotein receptors.

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