|
Molecular
and nano-scale drug-delivery systems 'MODELS' |
| Contract
number |
|
BRPR-CT97-0401 |
Proposal
number |
|
BE96-3621 |
| Start
date |
|
01-May-97 |
Duration |
|
3 years 6 months |
| RTD
programme |
|
Brite-EuRam |
| Coordinator |
|
Professor C Kiparissides |
|
Organisation |
|
Aristotle University of
Thessaloniki |
|
|
|
Department of Chemical
Engineering |
|
|
|
City University |
| Country |
|
Greece |
Postcode |
|
GR-540 06 |
| Telephone |
|
30 31 996212 / 996211 |
Fax |
|
30 31 996198 |
| Partner |
|
University of London, UK |
| Partner |
|
Albert-Ludwigs Unversitat,
DE |
| Partner |
|
NCSR Demokritos, GR |
| Summary |
|
The present programme aims
at the development of novel molecular / nano-scale controlled drug delivery systems based
on liposomes, dendrimers, lipid/polymer nanoaggregates, nano- and microspheres , in which
biologically active compounds will be incorporated, in order to find application in the
biomedical and pharmaceutical industries. |
| Achievements Updated April 1999 |
|
- Preparation of liposome formulations
incorporating the candidate drugs with/without the presence of a light absorber or/and
antioxidant. Complexation of drugs with cyclodextrins. Upscalled liposome production.
- Development of a new strategy of
releasing active compounds into target cells by using transiently induced destabilization
of cellular membranes by lipid / polymer nanoaggregates.
- Incoproration of the candidate drugs
within the molecular cavities of commercial or functionalized dendrimers.
- Development of efficient encapsulation
processes and detailed description of process operating conditions for the production of
five different types of micro- and nanospheres and microgels containing the candidate
drugs. Novel synthesis of composite microparticles with improved efficiency and stability
characteristics.
- In-vitro drug delivery studies from
liposomes, microparticles and microgels. Product evaluation studies.
|
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