|
Chemically
and physiologically inert oxygen-carrying |
|
perfluorocarbons
as body-fluid replacements |
| Contract
number |
|
BRE2-CT94-0943 |
Proposal
number |
|
BE-7318 |
| Start
date |
|
01-Jul-94 |
Duration |
|
3 years + 6 months |
| RTD
programme |
|
Brite-EuRam |
| Coordinator |
|
Prof Dr R-P Franke
(administrative co-ordinator) |
|
Prof . Cambon (University of
Nice, scientific co-ordinator) |
|
Organisation |
|
University of Ulm
Institute of Biomedical Technology |
|
Department |
|
Biomaterials Department |
| Street |
|
Albert-Einstein-Alle 47 |
| Country |
|
DE |
Postcode |
|
89081 |
| Telephone |
|
49 731 5025470 |
Fax |
|
49 731 5025351 |
| Partner |
|
University of Nice, FR |
| Partner |
|
University of Padova, I |
| Partner |
|
University of Nottingham,
UK |
| Partner |
|
Support has been received
from several companies, in the form of |
|
materials or support of
patent applications. |
| Summary |
|
To develop an
oxygen-carrying system based on PFCs or |
|
semifluorinated compounds
emulsified in physiological solutions, |
|
characterised by
sterilisability according to EP, improved long-term |
|
storage at ambient and
body temperatures, tailor-made compositions |
|
and quality for special
applications |
| Achievements |
|
The project has been
extremely productive of new emulsions of PFCs |
|
and new fluorinated and
semifluorinated surfactants that conform to |
|
the targets of the
project. Emulsions were steam-sterilisable and |
|
stable at room temperature
for over one year. A new manufacturing |
|
method was devised for
perfluorodimorpholinopropane. A new in vitro |
|
screen for biological
effects of PFCs has been developed and used to |
|
characterise novel
compounds. Some emulsions were assessed as |
|
perfusates for isolated
mammalian organs, where in vitro vital |
|
functions were markedly
improved. Some of the novel |
|
fluoro-surfactants
inhibited aggregation of human platelets in vitro in a |
Previous Next Last
  
|
