Institute of Physical Chemistry, National Centre for Science and Research
‘Demokritos’,
15310 Aghia Paraskevi, Attiki, Athens, Greece
Contact: Professor Dr Constantine Paleos
Email paleos@mail.demokritos.gr
Website: http://macedonia.nrcps.aridane-t.gr
Tel +30 1 6503666/6503653, Fax +30 1 6511766/6529792
Description of work: Our laboratory is
involved in the preparation and characterisation of materials of organised supramolecular
structure. The systems we develop are formed through self-assembly of specifically
functionalised molecules and include liquid crystals, micelles, liposomes and molecular
composites based on dendrimeric compounds. In most of the cases, the driving force for the
formation of these materials is the complementarity of the interacting molecules. Within
this framework, the current activities of our laboratory can be summarised in the
following:
- Development of drug delivery systems based on liposomes. Functionalisation of liposomes
and interactions of liposomes’ surfaces.
- Functionalisation of commercially available dendrimers and incorporation within their
cavities of appropriate probes or of biologically active materials for the development of
novel drug delivery systems.
- Formation of novel liquid crystals primarily through molecular recognition of
complementary molecules.
- Synthesis of amphotropic molecules i.e. compounds that can form supramolecular
organisates both in the bulk and in dispersio. Characterisation of the obtained
thermotropic or lyotropic liquid crystals as well as of functional micelles or liposomes.
Laboratory of Organized Supramolecular Mataerials
Among the activities of the Laboratory are included:
- Development of molecular composites based on synthetic vesicles,
liposomes, cyclodextrins or dendrimers.
- Drug release experiments with the systems mentioned above.
- Example project - Molecular and Nano-scale Drug Delivery Systems
Resources available:
- Well equipped synthetic laboratory.
- Characterisation methods include: Optical microscopy, Image processing, AFM and Scanning
Tunneling Microscopy, Methods of Thermal Analysis, UV-Vis Fluorescence, NMR and FT-IR
spectoscopies.
Products and technologies avaiable:
- Technology for the preparation of molecular composites based on liposomes, dentrimers
and cyclodextrins.
- Physicochemical characterizing of above aggregates.
Types of projects, collaborations wanted:
Collaborative projects for the clinical and, in general, biological evaluating of
systems mentioned above.
Selected Recent Publications:
A Kokkinia, C Keramaris, L Margaritis, A Malliaris and C M Paleos,
Formation and Characterisation of Simple and Mixed Vesicles Based on Monomeric and
Oligomeric Phosphate bipolar Amphiphiles, J Polym Sci., Chem Ed., 33, 455 (1995)
- C M Paleos, D Tsiourvas, Thermotropic Liquid Crystals Formed by Intermolecular Hydrogen
Bonding Interaction, Angew Chem Intern Engl Ed 34, 1696 (1995) (Review Article)
- G Pistolis, C M Paleos and A Malliaris, Molecular Recognition in Organic solvents The
importance of Excimer Fluorescence Spectroscopy, J Phys Chem., 99, 8896 (1995)
- Z Sideratou, C M Paleos and A Skoulios, Liquid Crystals from Non-mesogenic Anils Induced
through Hydrogen Bonding, Mol Cryst Liq Cryst 265, 19 (1995)
- C M Paleos, M Arkas, R Seghroushni and A Skoulios, Smectic Mesophases from Quaternary
Amphiphilic Ammonium Salts Functionalised with Interacting Endgroups, Mol Cryst Liq
Cryst., 268, 178 (1995)
- C M Paleos, Z Sideratou and D Tsiourvas, Mixed Vesicles of didodecyldimethlammonium
Bromide with Recognizable moieties at the Interface, J Phys Chem., 100, 13898 (1996)
- Z Sideratou, D Tsiourvas, C M Paleos and A Skoulios, Liquid Crystalline Behaviour of
Hydrogen-bonded Complexes of a Non-mesogenic Anil with p-n Alkoxybenzoic acids, Liquid
Crystals, 22, 51 (1996)
- D Tsiourvas, M Arkas, C M Paleos and A Skoulios, Smectic Mesomorphism of Long-chain
n-Alkylammonium Polyacrylates, Polymer Preprints, 38, 233 (1996)
- C M Paleos and D Tsiourvas, Molecular Recognition of Organised Assemblies via Hydrogen
Bonding in Aqueous Media, Advanced Materials, 9(9), 695 (1997) Review Article
- G Pistolis, A Malliaris, C M Paleos and D Tsiourvas, Study of Poly(amidoamine) Starburst
Dendrimers by Fluorescence Probing, Langmuir, 13(22), 5870 (1997)
- D Tsiourvas, C M Paleos and A Skoulios, Structural Study of Liquid Crystalline
Long-Chain n-Alkylammonium Polyacrylates, Macromolecules, 30, 7191 (1998)
- C M Paleos, M Arkas, and A Skoulios, Mesomorphic Character of Quaternary Ammonium Salts
affected by secondary hydrogen bonding interactions, Mol Cryst.Liq Cryst., 309, 237 (1998)
   
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