|
| Project name |
IsoBone:
A Tissue Engineered Living Bone Equivalent |
| Project reference |
Contract no |
BRPR-CT98-0719 |
Proposal no |
BE97-4612 |
| Start date |
01/06/98 |
Duration |
4 years |
| RTD programme |
Brite-EuRam |
| Project Co-ordinator
name |
Dr JD de Bruijn |
| Organisation address |
IsoTis BV |
|
Professor
Bronkhorstlaan 10 |
|
Bilthoven |
|
The Netherlands |
3723 MB |
| Telephone no |
31 30 2295229 |
|
| Fax no |
31 30 2280255 |
|
| Email |
joost.de.bruijn@isotis.com |
| Other partners |
Novamont SpA, I |
|
Twente
University, NL |
|
Cinpres Ltd, GB |
|
Brunel
University, GB |
|
INEB, P |
| Additional partners |
University of
Minho, P |
| Project summary |
This project is
aimed at developing living tissue-engineered bone substitute materials that can replace
load-bearing and non load-bearing bone |
| Project achievements
update April 99 |
- First biocompatible starch-based materials have been
identified and studies have been initiated to produce porous scaffolds using different
methods and to determine mechanical properties.
- First batches of PEO/PBT copolymer have been synthesised
on a small scale and studies have been initiated for pre-calcification and composite
preparation with calcium phosphates.
- Tissue culture experiments to optimise culture
conditions for rat and goat bone marrow cells have been performed and studies have been
initiated with rabbit and human bone marrow cells.
- Cell seeding experiments have started with static and
dynamic culture conditions to optimise cell seeding efficiencies.
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