| Project name |
Development
of novel matrices and encapsulatory materials for support and modulation of hair follicle
growth |
| Project reference |
Contract
no |
BRPR-CT97-0463 |
Proposal
no |
BE97-4301 |
| Start date |
01/06/97 |
Duration |
4 years |
| RTD programme |
Brite-EuRam |
| Budget (optional) |
1473400 |
| Project Co-ordinator
name |
Dr I McKay |
| Organisation address |
Queen Mary &
Westfield College |
|
Centre for
Cutaneous Research |
|
2 Newark Street |
|
London |
|
E1 2AT |
|
UK |
|
| Telephone no |
44 |
171 2957160 |
| Fax no |
44 |
171 2957171 |
| Email |
I.A.McKay@mds.qmw.ac.uk |
| Other partners |
L'Oréal
Recherche, F |
|
Humboldt-University,
Berlin, DE |
|
LEMI SA, F |
|
IsoTis BV, NL |
| Project summary |
This project aims
to develop over the contract period of four years, novel three-dimensional matrices that
will be used to support the in vitro growth of hair bearing skin-equivalents. |
| Project achievements
update April 99 |
- Established a database of matrices useful for support of hair
follicle proliferation.
- Established a database of methods for culture of hair follicles in
vitro and submitted an abstract to the EUROMAT 99 meeting entitled: ‘Hair
follicle culture: a critique of current systems and future trends’.
- Defined factors to be delivered to follicles to modulate their
proliferation and differentiation.
- Established a collection of hair follicles at different phases of
morphogenesis for analysis.
- Commenced investigations of the topobiology of the hair growth
cycle and submitted a paper to J. Histochem. Cytochem entitled: ‘ICAM-1 and hair
follicle regression: Upregulation of ICAM-1 expression during catagen, and catagen
acceleration in ICAM-1-deficient mice’.
- Commenced engineering of novel matrices for
support of hair follicle proliferation.
|
